Despite countless diets, and sincere efforts at weight loss, Americans are getting heavier each year. Obesity is one of the leading causes of preventable death in the US, second only to tobacco.

Designers of anti-obesity drugs have suffered three major setbacks, but the potential reward from treating the world's fat epidemic is so great that their quest is unlikely to be deterred.

An unidentified woman takes a walk in Washington,DC in 2007. Designers of anti-obesity drugs have suffered three major setbacks, but the potential reward from treating the world's fat epidemic is so great that their quest is unlikely to be deterred.

The commercials for Aspen Clinic include claims from customers and impressive before and after pictures, promoting successful personal weight loss stories.

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